https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36509 Wed 15 Dec 2021 16:07:52 AEDT ]]> Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18827 Wed 11 Apr 2018 13:01:16 AEST ]]> Shared genetic susceptibility to ischemic stroke and coronary artery disease : a genome-wide analysis of common variants https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21442 x10-8) for the combined phenotype of IS or CAD and 17 loci passed genome-wide significance for LAS or CAD. Because these loci had prior evidence for genome-wide significance for CAD, we specifically analyzed the respective signals for IS and LAS and found evidence for association at chr12q24/SH2B3 (PIS=1.62x10-7) and ABO (PIS=2.6x10-4), as well as at HDAC9 (PLAS=2.32x10-12), 9p21 (PLAS=3.70x10-6), RAI1-PEMT-RASD1 (PLAS=2.69x10-5), EDNRA (PLAS=7.29x10-4), and CYP17A1-CNNM2-NT5C2 (PLAS=4.9x10-4). Conclusions-Our results demonstrate substantial overlap in the genetic risk of IS and particularly the LAS subtype with CAD.]]> Sat 24 Mar 2018 08:05:46 AEDT ]]> Low-frequency and common genetic variation in ischemic stroke: the METASTROKE collaboration https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25883 Sat 24 Mar 2018 07:25:54 AEDT ]]> Heritability of young- and old-onset ischaemic stroke https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22849 P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.]]> Sat 24 Mar 2018 07:16:02 AEDT ]]>